Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843302 | 0.85 | LMNA (0.44) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL3842902 | 0.84 | HTT (0.42) | LMNAHTTTP53CYP2A6GABRA1 | |
| SCHEMBL13908891 | 0.82 | LMNA (0.44) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL14485295 | 0.80 | LMNA (0.42) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL10053114 | 0.80 | LMNA (0.42) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL14572026 | 0.78 | LMNA (0.41) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL26137536 | 0.78 | HTR1D (0.40) | LMNAHTTGABRA1IDO1ALOX12 | |
| SCHEMBL3849204 | 0.78 | SLC6A2 (0.50) | LMNACYP2A6SLC6A2SLC6A3 | |
| SCHEMBL7486888 | 0.77 | HTT (0.40) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL28135905 | 0.77 | SIRT1 (0.49) | LMNAHTTTP53HSP90AA1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190092765-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2019-03-28 | — | — | US | disclosed |
| EP-2838893-B1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2019-03-13 | — | — | EP | disclosed |
| US-10125126-B2 | N-cycloalkyl-N-[(heterocyclylphenyl)methylene]-(thio)carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2018-11-13 | — | — | US | disclosed |
| CN-104428294-B | N cycloalkyl N [(heterocyclyl phenyl) methylene] (thio) carboxamide derivative | 拜尔农科股份公司 | 2017-07-14 | — | — | CN | disclosed |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
| US-20150210678-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-07-30 | — | — | US | disclosed |
| CN-104428294-A | N-cycloalkyl-n-[(heterocyclylphenyl)methylene]-(thio)carboxamide derivatives | BAYER CROPSCIENCE AG | 2015-03-18 | — | — | CN | disclosed |
| EP-2838893-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | Bayer Cropscience AG (DE) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013156559-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2013-10-24 | — | — | WO | disclosed |
| US-6916806-B2 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20050124617-A1 | 2-Imino-1,3-thiazine derivatives | HANASAKI KOJI (JP) | 2005-06-09 | — | — | US | disclosed |
| US-20050101590-A1 | Cannabinoid receptor agonists | SHIONOGI & CO., LTD. (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1477186-A1 | ANTIPRURITICS | SHIONOGI & CO., LTD. (JP) | 2004-11-17 | — | — | EP | disclosed |
| US-6818640-B1 | BIND SELECTIVELY TO CANNABINOID 2 RECEPTOR; ANTIINFLAMMATORY AGENTS | SHIONOGI & CO., LTD. (JP) | 2004-11-16 | — | — | US | disclosed |
| CN-1514831-A | Medicinal composition containing 1,3-thiazine derivative | ��Ұ����ҩ��ʽ���� | 2004-07-21 | — | — | CN | disclosed |
| US-20040116326-A1 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1375489-A1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |
| CN-1387519-A | 2-imino-1, 3-thiazine derivatives | SHIONOGI & CO (JP) | 2002-12-25 | — | — | CN | disclosed |
| EP-1219612-A1 | 2-IMINO-1,3-THIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2002-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101590-A1 | Cannabinoid receptor agonists | CNR1, CNR2, OPRL1 | LMNA 4521/4885HTT 3822/4885TP53 4877/4885 |
| US-20150210678-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CBR1 | LMNA 2609/4885HTT 518/4885TP53 4449/4885 |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KRAS, HRAS, NRAS | LMNA 2826/4885HTT 2790/4885TP53 10/4885 |
| US-10125126-B2 | N-cycloalkyl-N-[(heterocyclylphenyl)methylene]-(thio)carboxamide derivatives | CBR3, NANP, CBR1 | LMNA 2609/4885HTT 518/4885TP53 4449/4885 |
| US-20050124617-A1 | 2-Imino-1,3-thiazine derivatives | CNR2, CNR1, HTR2C | LMNA 3850/4885HTT 2541/4885TP53 4771/4885 |
| US-20190092765-A1 | N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, CBR1, NANP | LMNA 2520/4885HTT 559/4885TP53 4412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.