Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1188309 | 0.78 | MMP13 (0.73) | MAPTPKMMMP13LMNAKDM4E | |
| SCHEMBL9343618 | 0.77 | PKM (1.00) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL14024262 | 0.77 | MAPT (0.77) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL3161812 | 0.76 | MAPT (0.74) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL1930857 | 0.76 | MAPT (0.74) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL30877538 | 0.76 | MMP13 (0.43) | MAPTPOLBPKMMMP13ELANE | |
| SCHEMBL13043174 | 0.75 | MMP13 (0.63) | MAPTPKMMMP13SMN1; SMN2MMP1 | |
| SCHEMBL65265 | 0.74 | MAPT (0.71) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL65266 | 0.74 | MAPT (0.71) | MAPTPOLBPKMLMNAELANE | |
| SCHEMBL3536505 | 0.74 | POLB (0.71) | MAPTPOLBPKMLMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116533-B1 | GLUCOKINASE ACTIVATOR | KYORIN SEIYAKU KK (JP) | 2013-07-10 | — | — | EP | disclosed |
| EP-2116533-A1 | GLUCOKINASE ACTIVATOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-11 | — | — | EP | disclosed |