Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3809843 | 0.74 | POLB (0.40) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL7150268 | 0.72 | POLB (0.41) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL7148744 | 0.71 | HTR6 (0.43) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL27564740 | 0.68 | POLB (0.52) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL3834077 | 0.68 | ALDH1A1 (0.50) | POLBHTR6PKMKMT2AALDH1A1 | |
| SCHEMBL3840584 | 0.67 | POLB (0.39) | POLBHTR6PKMKMT2AALDH1A1 | |
| SCHEMBL7196506 | 0.66 | POLB (0.47) | POLBHTR6KMT2AALDH1A1LMNA | |
| SCHEMBL7188016 | 0.66 | POLB (0.47) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL7188012 | 0.66 | POLB (0.47) | POLBHTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL3834082 | 0.65 | HTR6 (0.51) | POLBHTR6ALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235595-B8 | INTEGRIN-MEDIATED DRUG TARGETING | BAYER SCHERING PHARMA AG (DE) | 2009-10-07 | — | — | EP | disclosed |
| EP-1235595-A2 | INTEGRIN-MEDIATED DRUG TARGETING | Bayer Aktiengesellschaft (DE) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001017563-A2 | INTEGRIN-MEDIATED DRUG TARGETING | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-15 | — | — | WO | disclosed |