Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232994 | 0.86 | TAAR1 (0.37) | FFAR1 | |
| Hydrochloric Acid SCHEMBL610528 | 0.85 | HTR2C (0.38) | FFAR1 | |
| SCHEMBL3843367 | 0.85 | HRH3 (0.47) | HRH3CYP2D6FFAR1FFAR4KCNH2 | |
| SCHEMBL237488 | 0.82 | TAAR1 (0.38) | HRH3CYP2D6FFAR1 | |
| SCHEMBL3837471 | 0.82 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL3837719 | 0.81 | FFAR1 (0.41) | HRH3CYP2D6FFAR1 | |
| SCHEMBL610995 | 0.80 | KDM4E (0.44) | FFAR1KDM4E | |
| SCHEMBL3843357 | 0.78 | GRM5 (0.48) | HRH3CYP2D6FFAR1FFAR4KCNH2 | |
| SCHEMBL612960 | 0.78 | TAAR1 (0.39) | HRH3CYP2D6FFAR1 | |
| SCHEMBL3837696 | 0.77 | LPL (0.45) | CYP2D6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |