Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837471 | 0.90 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL234348 | 0.88 | HRH3 (0.43) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| Hydrochloric Acid SCHEMBL614043 | 0.86 | HRH3 (0.42) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL3843357 | 0.85 | GRM5 (0.48) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL3842200 | 0.85 | HRH3 (0.41) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL235578 | 0.83 | KCNH2 (0.43) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL3175981 | 0.82 | KCNH2 (0.46) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL3841194 | 0.81 | FFAR1 (0.44) | HRH3CYP2D6KCNH2FFAR1FFAR4 | |
| SCHEMBL3836753 | 0.80 | PTGES (0.47) | FFAR1FFAR4 | |
| SCHEMBL10751583 | 0.80 | KCNH2 (0.49) | HRH3CYP2D6KCNH2FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |