Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845476 | 0.91 | MAPK14 (0.39) | MAPK14SMPD1PPARGPPARAPLA2G4A | |
| SCHEMBL3845660 | 0.87 | S1PR1 (0.36) | PPARGPPARAS1PR1S1PR3S1PR4 | |
| SCHEMBL3842276 | 0.85 | TP53 (0.39) | PPARGPPARAS1PR1S1PR3PLA2G4A | |
| SCHEMBL3286654 | 0.85 | MAPK14 (0.38) | MAPK14SMPD1TSHRPDE4BADORA2A | |
| SCHEMBL3841090 | 0.84 | PPARG (0.47) | SMPD1PPARGPPARA | |
| SCHEMBL3846393 | 0.84 | TP53 (0.39) | PPARGPPARAS1PR1S1PR3PLA2G4A | |
| SCHEMBL3849869 | 0.82 | PPARG (0.38) | PPARGPPARAS1PR1S1PR3S1PR4 | |
| SCHEMBL3842665 | 0.82 | PPARG (0.46) | PPARGPPARATSHRTP53PLA2G4B | |
| SCHEMBL3846355 | 0.81 | PPARG (0.37) | PPARGPPARATP53ADORA3HTT | |
| SCHEMBL3285407 | 0.79 | PPARA (0.41) | SMPD1PPARGPPARATSHRPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |