Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.46 |
| ▸ | PPARG | P37231 | 8/20 | 0.46 |
| ▸ | PPARD | Q03181 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844300 | 0.96 | PPARA (0.47) | PPARAPPARGPPARDKCNH2CYP2D6 | |
| SCHEMBL3287502 | 0.95 | PPARA (0.48) | PPARAPPARGPPARDKCNH2CYP4F2 | |
| SCHEMBL3287490 | 0.90 | PPARA (0.49) | PPARAPPARGKCNH2CYP2D6 | |
| SCHEMBL3842289 | 0.90 | PPARG (0.39) | PPARAPPARGPPARDKCNH2CYP2D6 | |
| SCHEMBL3845816 | 0.89 | PPARA (0.47) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3842503 | 0.89 | PPARA (0.52) | PPARAPPARGPPARDKCNH2CYP2D6 | |
| SCHEMBL3844032 | 0.89 | PPARA (0.58) | PPARAPPARGPPARDCYP2D6CYP4F2 | |
| SCHEMBL3840604 | 0.89 | PPARA (0.47) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3849871 | 0.88 | PPARA (0.48) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3840894 | 0.87 | PPARA (0.45) | PPARAPPARGPPARDKCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |
| EP-1856065-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092507-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2006-09-08 | — | — | WO | disclosed |