Methacrylic Acid

Methacrylic Acid

SCHEMBL3843533

C(OCC1CO1)C1CO1.C=C(C)C(=O)O.O=P(O)(O)O

nearest known ligand 0.56

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
TSHR P16473 2/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.37
TP53 P04637 1/20 0.36
CYP3A4 P08684 1/20 0.36
ENPP2 Q13822 1/20 0.32
LPAR2 Q9HBW0 1/20 0.32
MGLL Q99685 2/20 0.32
PEPD P12955 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methacrylic Acid SCHEMBL236566 0.94 ALDH1A1 (0.61) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL2937502 0.94 ALDH1A1 (0.61) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL21811308 0.94 ALDH1A1 (0.61) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL234067 0.93 ALDH1A1 (0.59) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL6518776 0.91 ALDH1A1 (0.58) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL969068 0.89 ALDH1A1 (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL2923576 0.89 ALDH1A1 (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL28770114 0.89 ALDH1A1 (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL972419 0.89 ALDH1A1 (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1
Methacrylic Acid SCHEMBL10989721 0.89 ALDH1A1 (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2114357-A1 DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES Bisco, Inc. (US) 2009-11-11 EP disclosed
WO-2008094923-A1 DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES BISCO, INC. (US) 2008-08-07 WO disclosed
US-20080182922-A1 Dual Application Mode Self-Etch Dental Adhesives Compatible with Self-Cured and Dual-Cured Composites BISCO, INC. (US) 2008-07-31 US disclosed