Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852639 | 0.69 | KDM4C (0.39) | IKBKETBK1PIK3CAHPGDALOX5AP | |
| SCHEMBL28901178 | 0.69 | PLAU (0.38) | — | |
| SCHEMBL27872779 | 0.68 | CYP4F2 (0.32) | — | |
| SCHEMBL2891010 | 0.68 | CYP4F2 (0.33) | — | |
| SCHEMBL1954226 | 0.68 | ALOX5AP (0.35) | MAP3K12IKBKETBK1PIK3CAHPGD | |
| SCHEMBL6184983 | 0.68 | KMT2A (0.51) | FYNHPGD | |
| SCHEMBL12986494 | 0.66 | NPC1 (0.39) | FYN | |
| SCHEMBL28710658 | 0.65 | GRN (0.35) | — | |
| SCHEMBL27934670 | 0.64 | NPC1 (0.38) | — | |
| SCHEMBL28714021 | 0.64 | PIK3CA (0.37) | PIK3CAALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103288833-A | Imidazo triazines and imidazo pyrimidines as kinase inhibitors | INCYTE CORP | 2013-09-11 | — | — | CN | disclosed |
| CN-101641093-B | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP | 2013-05-29 | — | — | CN | disclosed |
| CN-101641093-A | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP US | 2010-02-03 | — | — | CN | disclosed |
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |