Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646701 | 0.79 | KMT2A (0.49) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL5647954 | 0.79 | SMN1; SMN2 (0.46) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL6628325 | 0.78 | KMT2A (0.44) | KMT2AL3MBTL1TDP1SMN1; SMN2KDM4E | |
| SCHEMBL5648637 | 0.77 | NPC1 (0.48) | KMT2AL3MBTL1TDP1SMN1; SMN2KDM4E | |
| SCHEMBL8814512 | 0.76 | L3MBTL1 (0.47) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL8814501 | 0.75 | KMT2A (0.46) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL9385111 | 0.72 | KMT2A (0.51) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL5651082 | 0.72 | SMN1; SMN2 (0.51) | KMT2AL3MBTL1TDP1SMN1; SMN2KDM4E | |
| SCHEMBL5648675 | 0.71 | KMT2A (0.54) | KMT2AL3MBTL1TDP1SMN1; SMN2FYN | |
| SCHEMBL28901178 | 0.69 | PLAU (0.38) | KMT2AL3MBTL1SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1732161-A | 1,3-diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARM INC (US) | 2006-02-08 | — | — | CN | claimed |
| EP-1534693-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004022523-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | claimed |
| CN-1732161-A | 1,3-diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARM INC (US) | 2006-02-08 | — | — | CN | disclosed |