Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987698 | 0.78 | NPSR1 (0.45) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2477624 | 0.75 | KDM4E (0.44) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2477627 | 0.75 | KDM4E (0.44) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2481869 | 0.74 | ALDH1A1 (0.43) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2481868 | 0.74 | ALDH1A1 (0.43) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8152251 | 0.70 | TAAR1 (0.50) | MEN1KMT2AKDM4ETAAR1ELANE | |
| SCHEMBL2481231 | 0.67 | NPC1 (0.48) | NPSR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2479796 | 0.67 | ALDH1A1 (0.43) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2479798 | 0.67 | ALDH1A1 (0.43) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7682170 | 0.66 | NPC1 (0.50) | NPSR1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114408-A1 | SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008091631-A1 | SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-07-31 | — | — | WO | disclosed |