Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAT1 | O14929 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030492 | 0.81 | NR4A2 (0.52) | MAPTNR4A2GABRA1GABRB1GABRA3 | |
| SCHEMBL1558918 | 0.77 | MAPT (0.46) | MAPTNR4A2GABRA1GABRB1GABRA3 | |
| SCHEMBL19983951 | 0.76 | TRPV1 (0.41) | TRPV1 | |
| SCHEMBL6029910 | 0.76 | MAPT (0.66) | MAPTNR4A2GABRA1GABRB1GABRA3 | |
| SCHEMBL6029993 | 0.75 | MEN1 (0.58) | HAT1EP300MAPTNR4A2TUBB1 | |
| SCHEMBL6028950 | 0.74 | MAPT (0.53) | MAPTNR4A2GABRA1GABRB1GABRA3 | |
| Hydrochloric Acid SCHEMBL14487414 | 0.74 | MEN1 (0.56) | HAT1EP300MAPTNR4A2TUBB1 | |
| SCHEMBL1558387 | 0.74 | MAPT (0.46) | HAT1EP300MAPTNR4A2TUBB1 | |
| SCHEMBL17338592 | 0.74 | KDM4E (0.52) | GABRA1GABRB1GABRA3GABRB2TRPV1 | |
| SCHEMBL4650158 | 0.73 | GABRA1 (0.58) | GABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010171-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | Wyeth a Corporation of the State of Delaware (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007098278-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | WYETH (US) | 2007-08-30 | — | — | WO | disclosed |