Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825254 | 0.82 | DYRK1A (0.36) | SMN1; SMN2RAB9ANPC1FYNDYRK1A | |
| SCHEMBL17027901 | 0.69 | IDO1 (0.58) | SMN1; SMN2RAB9ANPC1IDO1METAP2 | |
| SCHEMBL22290686 | 0.68 | IDO1 (0.43) | SMN1; SMN2RAB9ANPC1HCRTR1CASP3 | |
| SCHEMBL22053018 | 0.64 | IDO1 (0.49) | SMN1; SMN2RAB9ANPC1HCRTR1CASP3 | |
| SCHEMBL2658449 | 0.63 | IDO1 (0.47) | SMN1; SMN2RAB9ANPC1HCRTR1CASP3 | |
| SCHEMBL14834449 | 0.63 | IDO1 (0.44) | SMN1; SMN2RAB9ANPC1HCRTR1CASP3 | |
| SCHEMBL6106706 | 0.63 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1HCRTR1CASP3 | |
| SCHEMBL2404693 | 0.62 | SLC6A2 (0.51) | SMN1; SMN2RAB9AIDO1METAP2MAPT | |
| SCHEMBL1925054 | 0.62 | IDO1 (0.53) | SMN1; SMN2RAB9ANPC1IDO1METAP2 | |
| SCHEMBL19903831 | 0.61 | FYN (0.49) | KDM4EIDO1FYNGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |