Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11511523 | 0.83 | FYN (0.47) | FYNBCHEACHEPIM1KDM4E | |
| SCHEMBL23535571 | 0.81 | FYN (0.64) | FYN | |
| SCHEMBL4497709 | 0.77 | MET (0.50) | FYNBCHEACHEIDO1MET | |
| SCHEMBL19903870 | 0.73 | MET (0.48) | PIM1KDM4EHSD17B10MET | |
| SCHEMBL23535554 | 0.69 | FYN (0.83) | FYN | |
| SCHEMBL842168 | 0.68 | CYP2A6 (0.57) | BCHEACHEPIM1IDO1KDM4E | |
| SCHEMBL328396 | 0.68 | HPGDS (0.56) | BCHEACHEPIM1IDO1MET | |
| SCHEMBL11628686 | 0.68 | KDM4E (0.69) | FYNKDM4EHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL11469493 | 0.68 | MAP4K4 (0.49) | FYNGAA | |
| SCHEMBL102704 | 0.68 | FYN (0.87) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287449-A2 | SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME | Incyte Holdings Corporation (US) | 2018-02-28 | — | — | EP | disclosed |