Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805709 | 0.94 | P2RX7 (0.66) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL3837459 | 0.85 | P2RX7 (0.69) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| Trifluoroacetic Acid SCHEMBL3836980 | 0.81 | P2RX7 (0.52) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL3839544 | 0.80 | P2RX7 (0.65) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL3842138 | 0.78 | P2RX7 (0.52) | P2RX7CSNK1DKCNJ11L3MBTL1ROCK2 | |
| SCHEMBL3837070 | 0.78 | P2RX7 (0.63) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL1804074 | 0.78 | P2RX7 (0.62) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| Trifluoroacetic Acid SCHEMBL3837888 | 0.77 | P2RX7 (0.51) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL1801630 | 0.77 | P2RX7 (0.76) | P2RX7CSNK1DKCNJ11L3MBTL1EPHX2 | |
| SCHEMBL3839511 | 0.76 | P2RX7 (0.55) | P2RX7NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-B1 | P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2009-10-28 | — | — | EP | claimed |