Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804659 | 0.95 | P2RX7 (0.57) | P2RX7MCHR1KMT2AHSD11B1L3MBTL1 | |
| SCHEMBL3843290 | 0.85 | P2RX7 (0.53) | P2RX7MCHR1CSNK1DKCNJ11L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL3842236 | 0.82 | P2RX7 (0.58) | P2RX7 | |
| SCHEMBL5098673 | 0.82 | P2RX7 (0.57) | P2RX7KMT2AL3MBTL1EPHX2KCNQ3 | |
| SCHEMBL1803211 | 0.81 | P2RX7 (0.54) | P2RX7KMT2AL3MBTL1EPHX2KCNQ3 | |
| Trifluoroacetic Acid SCHEMBL3843940 | 0.81 | P2RX7 (0.60) | P2RX7CSNK1DKMT2AKCNJ11L3MBTL1 | |
| SCHEMBL1801178 | 0.79 | P2RX7 (0.59) | P2RX7KMT2AL3MBTL1EPHX2KCNQ3 | |
| SCHEMBL1805833 | 0.79 | P2RX7 (0.58) | P2RX7HSD11B1L3MBTL1EPHX2KCNQ3 | |
| SCHEMBL3843656 | 0.79 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL1806664 | 0.78 | P2RX7 (0.59) | P2RX7HSD11B1L3MBTL1EPHX2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-B1 | P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2009-10-28 | — | — | EP | claimed |