Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842355 | 0.95 | PPARG (0.41) | PPARGPPARAPPARDTP53ADORA3 | |
| SCHEMBL3843493 | 0.93 | PPARG (0.37) | PPARGPPARAS1PR2S1PR4S1PR1 | |
| SCHEMBL3284391 | 0.92 | PPARA (0.38) | PPARGPPARATP53ADORA3 | |
| SCHEMBL3844552 | 0.91 | SLC22A12 (0.34) | PPARGPPARAPPARDTP53 | |
| SCHEMBL3842827 | 0.90 | PPARG (0.40) | PPARGPPARAPPARDTP53ADORA3 | |
| SCHEMBL3843417 | 0.90 | PPARA (0.44) | PPARGPPARAPPARDTP53ADORA3 | |
| SCHEMBL3285913 | 0.89 | TPSAB1 (0.32) | PPARGPPARAPPARD | |
| SCHEMBL3841181 | 0.89 | MAOA (0.35) | PPARAPPARD | |
| SCHEMBL3849410 | 0.88 | PPARG (0.40) | PPARGPPARAS1PR2S1PR4S1PR1 | |
| SCHEMBL3841330 | 0.88 | PPARG (0.38) | PPARGPPARAPPARDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2007-11-21 | — | — | EP | claimed |
| WO-2006092507-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2006-09-08 | — | — | WO | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |