Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.39 |
| ▸ | SELP | P16109 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844896 | 1.00 | USP1 (0.40) | USP1PRKCQTYRO3SELPCHEK1 | |
| SCHEMBL3855274 | 0.92 | PRKCQ (0.41) | USP1PRKCQTYRO3SELPCHEK1 | |
| SCHEMBL13608108 | 0.89 | DDR1 (0.44) | USP1PRKCQTYRO3SELPCHEK1 | |
| SCHEMBL13845144 | 0.89 | DDR1 (0.44) | USP1PRKCQTYRO3SELPCHEK1 | |
| SCHEMBL13608105 | 0.88 | PRKCQ (0.53) | PRKCQCDK2CSNK1DGSK3B | |
| SCHEMBL13608128 | 0.88 | PRKCQ (0.53) | PRKCQCDK2CSNK1DGSK3B | |
| SCHEMBL3846527 | 0.88 | PRKCQ (0.45) | PRKCQPAK4CDK2CSNK1DGSK3B | |
| SCHEMBL13608144 | 0.88 | PRKCQ (0.45) | PRKCQPAK4CDK2CSNK1DGSK3B | |
| SCHEMBL13608111 | 0.88 | PRKCQ (0.45) | PRKCQPAK4CDK2CSNK1DGSK3B | |
| SCHEMBL3849036 | 0.88 | PRKCQ (0.53) | PRKCQCDK2CSNK1DGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | USP1 3253/4885PRKCQ 3/4885TYRO3 2858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.