Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL3781327 | 1.00 | — | — | |
| Dalfampridine SCHEMBL53483 | 0.96 | — | — | |
| Dalfampridine SCHEMBL1442620 | 0.96 | MAPT (1.00) | — | |
| Dalfampridine SCHEMBL7987482 | 0.93 | — | — | |
| Dalfampridine SCHEMBL28757299 | 0.93 | MAPT (0.93) | — | |
| Dalfampridine SCHEMBL28976215 | 0.93 | — | — | |
| Dalfampridine SCHEMBL8968143 | 0.93 | — | — | |
| Dalfampridine SCHEMBL31012422 | 0.93 | — | — | |
| Dalfampridine SCHEMBL7113651 | 0.93 | — | — | |
| Dalfampridine SCHEMBL28750367 | 0.93 | MAPT (0.93) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107326393-B | A kind of preparation method of water power parsing oxygen non-precious metal catalyst | 广西大学 | 2019-08-23 | — | — | CN | claimed |
| CN-106915735-A | A kind of preparation method of nitrogen or metal-doped carbon material | 广西大学 | 2017-07-04 | — | — | CN | claimed |
| US-20160235735-A1 | TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND FAMPRIDINE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2016-08-18 | — | — | US | claimed |
| CN-104059017-B | A kind of complexing salt and prepare the method for high molecular polyparaphenylene pyridobisimidazole | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-03-02 | — | — | CN | claimed |
| CN-103224625-B | The preparation method of poly-(2,5-dihydroxy-1,4-pyridobismidazole) | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-09-30 | — | — | CN | claimed |
| CN-103588703-B | A kind of 2,3,5,6-4-aminopyridine method for production of phosphate salt | China Bluestar Chengrand Research Institute of Chemical Industry Co., Ltd. (CN) | 2015-08-05 | — | — | CN | claimed |
| EP-2872217-A1 | TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND FAMPRIDINE | Teva Pharmaceutical Industries Ltd. (IL) | 2015-05-20 | — | — | EP | claimed |
| CN-104582793-A | Treatment of multiple sclerosis with combination of laquinimod and fampridine | TEVA PHARMA | 2015-04-29 | — | — | CN | claimed |
| CN-103243410-B | Preparation method of high-performance organic fibers on basis of 2,3,5,6-tetraaminopyridine hydrochloride | UNIV HEILONGJIANG | 2015-04-15 | — | — | CN | claimed |
| CN-104059017-A | Complex salt and method for preparing high-molecular-weight poly-p-phenylenepyridino-bisiminazole (PIPD) from same | UNIV NANJING SCIENCE & TECH | 2014-09-24 | — | — | CN | claimed |
| CN-103483249-A | Synthetic method for 2, 3, 5, 6-tetraaminopyridine hydrochloride | UNIV NANJING SCIENCE & TECH | 2014-01-01 | — | — | CN | claimed |
| CN-103243410-A | Preparation method of high-performance organic fibers on basis of 2,3,5,6-tetraaminopyridine hydrochloride | UNIV HEILONGJIANG | 2013-08-14 | — | — | CN | claimed |
| CN-103224625-A | Preparation method for poly(2,5-dihydroxyl-1,4-phenylene pyridobisimidazole) | UNIV NANJING SCIENCE & TECH | 2013-07-31 | — | — | CN | claimed |
| CN-102731377-A | Method for preparing 2, 3, 5, 6-tetraaminopyrimidine hydrochloride | SINOCHEM CORP | 2012-10-17 | — | — | CN | claimed |
| CN-102516540-A | Method for grafting SWNT (single-walled carbon nanotube) into modified PIPD (poly[2,5-dihydroxy-1,4-phenylenepyridinodiimidazole]) | HARBIN INST OF TECHNOLOGY | 2012-06-27 | — | — | CN | claimed |
| CN-101418073-B | Method for preparing poly(2,5-dihydroxy-1,4-pyridobismidazole) | HARBIN INST OF TECHNOLOGY | 2011-05-18 | — | — | CN | claimed |
| CN-101418073-A | Method for preparing poly(2,5-dihydroxy-1,4-pyridobismidazole) | HARBIN INST OF TECHNOLOGY (CN) | 2009-04-29 | — | — | CN | claimed |
| CN-101417973-A | Method for preparing 2,3,5,6-tetra aminopyridine-2,5-dihydroxy terephthalate | HARBIN INST OF TECHNOLOGY (CN) | 2009-04-29 | — | — | CN | claimed |
| CN-101289419-A | Process for preparing 2,3,5,6-tetraminopyridine hydrochloride | HARBIN INST OF TECHNOLOGY (CN) | 2008-10-22 | — | — | CN | claimed |
| WO-2002072025-A2 | IMPROVING POSTSYNAPTIC RESPONSE BY A COMBINATION OF 4-MINOPYRIDINE AND AGONIST | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) | 2002-09-19 | — | — | WO | claimed |