Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL1442620 | 1.00 | MAPT (1.00) | — | |
| Dalfampridine SCHEMBL28750367 | 0.96 | MAPT (0.93) | — | |
| Dalfampridine SCHEMBL7113651 | 0.96 | — | — | |
| Dalfampridine SCHEMBL28976215 | 0.96 | — | — | |
| Dalfampridine SCHEMBL31012422 | 0.96 | — | — | |
| Dalfampridine SCHEMBL3845825 | 0.96 | — | — | |
| Dalfampridine SCHEMBL7987482 | 0.96 | — | — | |
| Dalfampridine SCHEMBL8968143 | 0.96 | — | — | |
| Dalfampridine SCHEMBL28757299 | 0.96 | MAPT (0.93) | — | |
| Dalfampridine SCHEMBL28799379 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 29670 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747282-A1 | ACTIVATABLE TYROSINE-PROTEIN KINASE MEMBRANE RECEPTOR (ROR) ANTIBODY-DRUG CONJUGATES AND USES THEREOF | Exelixis, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4746922-A2 | INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2 ANTIBODY-DRUG CONJUGATES AND USES THEREOF | Exelixis, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747283-A1 | TYROSINE-PROTEIN KINASE MEMBRANE RECEPTOR 1 (ROR1) ANTIBODY-DRUG CONJUGATES AND USES THEREOF | Exelixis, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122079311-A | Aeration-free low-current-density electrocatalytic oxidation water treatment method and electrocatalytic film | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260137082-A1 | FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL | SYNGENTA CROP PROTECTION AG (CH) | 2026-05-21 | — | — | US | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| CN-121021045-B | Mixed fiber regenerated asphalt mixture and preparation and application thereof | 中交四航局第一工程有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119409664-B | Preparation method of double-electric ionic liquid corrosion inhibition bactericide | 中国石油大学(华东) | 2026-05-19 | — | — | CN | claimed |
| CN-119926528-B | Regeneration modification method of waste catalytic cracking catalyst and dechlorination method of high-chlorine diesel | 中国石油化工股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-0013408-B1 | 4-AMINOPYRIDINES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-26 | — | — | EP | claimed |
| US-4289765-A | BRONCHOSPASMOLYTIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | claimed |
| US-4260652-A | POLYBENZIMIDAZOLONES | TEIJIN LIMITED (JP) | 1981-04-07 | — | — | US | claimed |
| EP-0013408-A1 | 4-Aminopyridines, process for their preparation and drugs containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | claimed |
| US-4119478-A | COLORLESS COMPOUND CONTAINING ONE OR MORE BASIC NITROGEN ATOMS ATTACHED TO CARBON IN PYRIDINE OR BENZIMIDAZOLE RING AND HAVING ONE OR MORE UREA OR URETHANE GROUPS | CIBA-GEIGY CORPORATION (US) | 1978-10-10 | — | — | US | claimed |
| US-4107313-A | α,α-Bis-[4-(R-amino)-1-pyridinium]xylenes and antibacterial and antifungal uses | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | claimed |
| US-4039483-A | Method of producing an ion exchanger by reacting unsaturated vulcanized or powdered rubbers with iodine isocyanate and then introducing ion exchange groups by further reaction | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1977-08-02 | — | — | US | claimed |
| US-4025509-A | Aminopyridinium acetyl cephalosporanes | CIBA-GEIGY CORPORATION (US) | 1977-05-24 | — | — | US | claimed |
| US-RE29119-E | 7-Pyridinium methyl carboxyl derivatives of 7-amino-cephalosporanic acid | CIBA-GEIGY CORPORATION (US) | 1977-01-18 | — | — | US | claimed |
| US-3966726-A | Process for the production of cyclic carboxylic acid imides | AKZO N.V. (NL) | 1976-06-29 | — | — | US | claimed |