SCHEMBL3845840

SCHEMBL3845840

Fc1ccccc1-c1n[nH]cc1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DCUN1D1 Q96GG9 3/20 0.41
IDO1 P14902 1/20 0.41
HTR7 P34969 2/20 0.40
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
PIM1 P11309 2/20 0.38
NOTUM Q6P988 1/20 0.38
CHUK O15111 1/20 0.38
ADORA2A P29274 2/20 0.37
MBNL1 Q9NR56 1/20 0.37
PIK3CD O00329 1/20 0.36
PIK3R1 P27986 1/20 0.36
PIK3CA P42336 1/20 0.36
PIK3CB P42338 1/20 0.36
PIK3CG P48736 1/20 0.36
NISCH Q9Y2I1 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30590778 1.00 DCUN1D1 (0.41) DCUN1D1IDO1HTR7HPGDSMN1; SMN2
SCHEMBL3845897 0.79 TTR (0.32)
SCHEMBL30590844 0.79 PKM (0.32) IDO1SMN1; SMN2MAPTPIK3R1PIK3CA
SCHEMBL3844647 0.79 PKM (0.32) IDO1SMN1; SMN2MAPTPIK3R1PIK3CA
SCHEMBL11625109 0.78 MBNL1 (0.47) DCUN1D1IDO1HTR7SMN1; SMN2MAPT
SCHEMBL8883443 0.78 IDO1 (0.42) DCUN1D1IDO1HTR7HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL23701631 0.76 ADORA2A (0.42) DCUN1D1IDO1HTR7PIM1NOTUM
SCHEMBL3846772 0.76 MEN1 (0.34) HPGDSMN1; SMN2MEN1MAPTKMT2A
SCHEMBL11620496 0.74 HSP90AA1 (0.46) DCUN1D1IDO1HTR7HPGDSMN1; SMN2
SCHEMBL15182849 0.74 PIM1 (0.39) DCUN1D1IDO1HTR7HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250236608-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2025-07-24 US disclosed
WO-2023196283-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION (US) 2023-10-12 WO disclosed
WO-2023196283-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION (US) 2023-10-12 WO disclosed
EP-2048142-A2 Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof Eisai R&D Management Co., Ltd. (JP) 2009-04-15 EP disclosed
EP-1382603-B1 NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF EISAI R&D MAN CO LTD (JP) 2008-07-23 EP disclosed
EP-1382603-B1 NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF EISAI R&D MAN CO LTD (JP) 2008-07-23 EP disclosed
US-7074801-B1 Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof EISAI CO., LTD. (JP) 2006-07-11 US disclosed
EP-1382603-A1 NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF Eisai Co., Ltd. (JP) 2004-01-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250236608-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 DCUN1D1 1987/4885IDO1 4371/4885HTR7 3155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.