Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845882 | 0.89 | TGFBR1 (0.36) | TGFBR1TGFBR2 | |
| SCHEMBL3848408 | 0.88 | TGFBR1 (0.36) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL3853919 | 0.87 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL3847131 | 0.85 | KCNH2 (0.41) | TGFBR1FLT3 | |
| SCHEMBL3847945 | 0.85 | SMN1; SMN2 (0.34) | TGFBR1MAPK14 | |
| SCHEMBL3847341 | 0.85 | TGFBR1 (0.48) | TGFBR1TGFBR2 | |
| SCHEMBL3845245 | 0.85 | FLT3 (0.39) | TGFBR1FLT3MAPK14TGFBR2 | |
| SCHEMBL3848635 | 0.84 | TGFBR1 (0.45) | TGFBR1TGFBR2 | |
| SCHEMBL3850397 | 0.84 | FLT3 (0.43) | TGFBR1FLT3MAPK14TGFBR2 | |
| SCHEMBL3846734 | 0.84 | MKNK1 (0.44) | TGFBR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |