Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.60 |
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.52 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736227 | 1.00 | L3MBTL1 (0.60) | L3MBTL1L3MBTL3TDP1HRH3KDM4E | |
| SCHEMBL1735977 | 0.99 | L3MBTL1 (0.59) | L3MBTL1L3MBTL3TDP1HRH3KDM4E | |
| SCHEMBL3843544 | 0.99 | L3MBTL1 (0.59) | L3MBTL1L3MBTL3TDP1HRH3KDM4E | |
| SCHEMBL3862100 | 0.89 | L3MBTL1 (0.70) | L3MBTL1L3MBTL3HRH3KDM4EMEN1 | |
| SCHEMBL1735966 | 0.89 | L3MBTL1 (0.70) | L3MBTL1L3MBTL3HRH3KDM4EMEN1 | |
| SCHEMBL1735976 | 0.89 | L3MBTL1 (0.70) | L3MBTL1L3MBTL3HRH3KDM4EMEN1 | |
| SCHEMBL3846297 | 0.89 | L3MBTL1 (0.70) | L3MBTL1L3MBTL3HRH3KDM4EMEN1 | |
| SCHEMBL1735125 | 0.87 | L3MBTL3 (0.71) | L3MBTL1L3MBTL3HRH3MEN1KMT2A | |
| SCHEMBL3841287 | 0.87 | L3MBTL3 (0.71) | L3MBTL1L3MBTL3HRH3MEN1KMT2A | |
| SCHEMBL3882975 | 0.87 | L3MBTL3 (0.60) | L3MBTL1L3MBTL3TDP1HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027086-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| WO-2007136668-A2 | N-BENZOYL-AND N-BENZYLPYRROLIDIN-3-YLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-11-29 | — | — | WO | claimed |