Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849706 | 0.86 | FLT3 (0.46) | CDK2DYRK1AFLT3 | |
| SCHEMBL3847481 | 0.86 | TGFBR1 (0.40) | TGFBR1TGFBR2CSNK1DCSNK1EFLT3 | |
| SCHEMBL3846723 | 0.85 | KDR (0.39) | KDRTGFBR1TGFBR2CSNK1DCSNK1E | |
| SCHEMBL3854603 | 0.84 | EIF2AK4 (0.46) | TGFBR1CSNK1DCSNK1EIRAK4FLT3 | |
| SCHEMBL3846497 | 0.83 | FYN (0.41) | FLT3 | |
| SCHEMBL6644463 | 0.82 | MAPK14 (0.41) | TGFBR1CSNK1DCSNK1EFLT3 | |
| SCHEMBL3849253 | 0.82 | FLT3 (0.38) | TGFBR1DYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL3848318 | 0.82 | IRAK4 (0.44) | KDRTGFBR1TGFBR2IRAK4DYRK3 | |
| SCHEMBL3845287 | 0.82 | IRAK4 (0.44) | KDRTGFBR1TGFBR2IRAK4DYRK3 | |
| SCHEMBL3845245 | 0.82 | FLT3 (0.39) | TGFBR1TGFBR2CSNK1DCSNK1EFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |