Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.34 |
| ▸ | NRAS | P01111 | 3/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849709 | 0.89 | FLT3 (0.38) | TGFBR1IRAK4TGFBR2FLT3CDK2 | |
| SCHEMBL3847482 | 0.89 | TGFBR1 (0.34) | TGFBR1IRAK4CSNK1DCSNK1ETGFBR2 | |
| SCHEMBL3854606 | 0.87 | EIF2AK4 (0.40) | IRAK4CSNK1DCSNK1EFLT3NRAS | |
| SCHEMBL3849638 | 0.86 | FYN (0.35) | — | |
| SCHEMBL3845247 | 0.86 | FLT3 (0.31) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3846112 | 0.85 | FLT3 (0.34) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3846737 | 0.85 | MKNK1 (0.36) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3850400 | 0.85 | FLT3 (0.35) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3846719 | 0.85 | KDR (0.46) | KDRTGFBR1IRAK4CSNK1DCSNK1E | |
| SCHEMBL3845523 | 0.85 | FLT3 (0.33) | TGFBR1TGFBR2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |