Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843879 | 0.89 | KCNH2 (0.34) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15121631 | 0.83 | KCNH2 (0.39) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3843307 | 0.81 | ALDH1A1 (0.40) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3839920 | 0.77 | KCNH2 (0.48) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3843825 | 0.77 | KCNH2 (0.41) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3844362 | 0.76 | KCNH2 (0.37) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4145112 | 0.74 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL4136633 | 0.73 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL3517716 | 0.72 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL5047886 | 0.72 | SIGMAR1 (0.38) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |