Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 9/20 | 0.33 |
| ▸ | IP6K3 | Q96PC2 | 7/20 | 0.33 |
| ▸ | IP6K2 | Q9UHH9 | 7/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846131 | 0.85 | MEN1 (0.38) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3852914 | 0.84 | MEN1 (0.38) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3847041 | 0.81 | MEN1 (0.46) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3846777 | 0.79 | ATM (0.36) | ALDH1A1HPGDMAPK1MAPK10 | |
| SCHEMBL3846738 | 0.73 | ACHE (0.39) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3845226 | 0.73 | PIK3CD (0.32) | — | |
| SCHEMBL3846526 | 0.73 | MAPKAPK2 (0.39) | MEN1KMT2ALMNAALDH1A1USP2 | |
| SCHEMBL3846797 | 0.73 | CYP3A4 (0.49) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3846403 | 0.72 | LRRK2 (0.31) | — | |
| SCHEMBL3850389 | 0.71 | MAPKAPK2 (0.39) | SMN1; SMN2ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |