Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 10/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 8/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 8/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846130 | 0.81 | MEN1 (0.44) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3847045 | 0.81 | MEN1 (0.39) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3852911 | 0.80 | MEN1 (0.44) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1750818 | 0.79 | NR3C1 (0.38) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3846776 | 0.73 | ATM (0.41) | ALDH1A1HPGD | |
| SCHEMBL29771432 | 0.72 | L3MBTL1 (0.41) | MEN1KMT2ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL70574 | 0.69 | L3MBTL1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8655645 | 0.68 | MEN1 (0.56) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8320062 | 0.68 | AXL (0.54) | — | |
| SCHEMBL3846273 | 0.68 | MEN1 (0.54) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |