Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.32 |
| ▸ | NRAS | P01111 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847482 | 0.92 | TGFBR1 (0.34) | TGFBR1TGFBR2FLT3NRASIRAK4 | |
| SCHEMBL3847229 | 0.90 | TGFBR1 (0.37) | TGFBR1TGFBR2FLT3IRAK4 | |
| SCHEMBL3850696 | 0.90 | TGFBR1 (0.35) | TGFBR1TGFBR2FLT3NRASIRAK4 | |
| SCHEMBL3850400 | 0.88 | FLT3 (0.35) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3850101 | 0.88 | TGFBR1 (0.33) | TGFBR1TGFBR2FLT3NRASIRAK4 | |
| SCHEMBL3848181 | 0.85 | FLT3 (0.39) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3846419 | 0.85 | MKNK1 (0.46) | IRAK4 | |
| SCHEMBL3845247 | 0.84 | FLT3 (0.31) | TGFBR1TGFBR2FLT3 | |
| SCHEMBL3846843 | 0.83 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL3846723 | 0.81 | KDR (0.39) | TGFBR1TGFBR2FLT3NRASIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |