Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138839 | 0.81 | EGFR (0.43) | EGFRERBB2NPC1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL1893474 | 0.78 | KDR (0.42) | EGFRCLK1KDRRETKIF5B | |
| SCHEMBL29368280 | 0.77 | EGFR (0.72) | EGFRCLK1KDRRETKIF5B | |
| SCHEMBL159652 | 0.75 | KDR (0.80) | EGFRERBB2KDRRETKIF5B | |
| Hydrochloric Acid SCHEMBL1468204 | 0.74 | KDR (0.78) | EGFRERBB2KDRRETKIF5B | |
| SCHEMBL7499766 | 0.74 | ALDH1A1 (0.51) | EGFRERBB2NPC1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL8708549 | 0.73 | KDR (0.49) | EGFRERBB2KDRRETKIF5B | |
| SCHEMBL6471210 | 0.73 | EGFR (0.50) | EGFRERBB2NPC1MAPTKMT2A | |
| SCHEMBL31006585 | 0.72 | NPC1 (0.76) | EGFRCLK1KDRRETKIF5B | |
| SCHEMBL29283856 | 0.72 | NPC1 (0.76) | EGFRCLK1KDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943240-B1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2009-11-11 | — | — | EP | disclosed |