Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.79 |
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | GLA | P06280 | 3/20 | 0.78 |
| ▸ | RECQL | P46063 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | HBB | P68871 | 3/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | USP2 | O75604 | 2/20 | 0.76 |
| ▸ | CASP1 | P29466 | 2/20 | 0.76 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.76 |
| ▸ | CASP7 | P55210 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27625556 | 1.00 | TOP1 (0.79) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27489142 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3847426 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27864931 | 0.91 | TOP1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27363066 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8204358 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8490531 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6829424 | 0.90 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27479559 | 0.89 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27363068 | 0.89 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | claimed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| EP-1007035-A4 | POLYTHIOPHENE ANTI-TUMOR AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2000-11-22 | — | — | EP | disclosed |
| EP-1007035-A1 | POLYTHIOPHENE ANTI-TUMOR AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998023269-A1 | POLYTHIOPHENE ANTI-TUMOR AGENTS | PURDUE RESEARCH FOUNDATION (US) | 1998-06-04 | — | — | WO | disclosed |
| US-5741811-A | ADMINISTERING TO CANCER PATIENTS | PURDUE RESEARCH FOUNDATION (US) | 1998-04-21 | — | — | US | disclosed |
| US-5578636-A | Polythiophene anti-tumor agents | PURDUE RESEARCH FOUNDATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0321122-B1 | Water soluble camptothecin analogs | SMITHKLINE BEECHAM CORP (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5004758-A | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells | SMITHKLINE BEECHAM CORPORATION (US) | 1991-04-02 | — | — | US | disclosed |
| EP-0321122-A2 | Water soluble camptothecin analogs | SMITHKLINE BEECHAM CORPORATION (US) | 1989-06-21 | — | — | EP | disclosed |