Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 17/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.81 |
| ▸ | RECQL | P46063 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.81 |
| ▸ | BLM | P54132 | 2/20 | 0.81 |
| ▸ | GLA | P06280 | 4/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.74 |
| ▸ | ACHE | P22303 | 1/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847426 | 0.94 | TOP1 (0.85) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL27489142 | 0.94 | TOP1 (0.85) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL27864931 | 0.92 | TOP1 (0.82) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL8204358 | 0.92 | TOP1 (0.81) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL27363066 | 0.92 | TOP1 (0.81) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL27479559 | 0.91 | TOP1 (0.80) | TOP1KDM4ERECQLTDP1POLB | |
| Hydrochloric Acid SCHEMBL27363068 | 0.91 | TOP1 (0.80) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL5324470 | 0.90 | TOP1 (0.79) | TOP1KDM4ERECQLTDP1POLB | |
| Karenitecin SCHEMBL29537807 | 0.90 | TOP1 (0.79) | TOP1KDM4ERECQLTDP1POLB | |
| SCHEMBL27625556 | 0.90 | TOP1 (0.79) | TOP1KDM4ERECQLTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999052861-A1 | NOVEL BENZYL GUANIDINE DERIVATIVES FOR THERAPY AND IN-VIVO AND IN-VITRO DIAGNOSIS | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin (DE) | 1999-10-21 | — | — | WO | disclosed |