Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.48 |
| ▸ | EIF2AK4 | Q9P2K8 | 5/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768686 | 0.83 | MAP3K14 (0.48) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3851193 | 0.82 | MAP3K14 (0.48) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3847808 | 0.81 | POLB (0.49) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3847032 | 0.80 | MAP3K14 (0.45) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL19586824 | 0.80 | MAP3K14 (0.45) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3846525 | 0.80 | MAP3K14 (0.48) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3846263 | 0.79 | PIK3CA (0.42) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3849418 | 0.78 | NR1H4 (0.52) | PIK3CAMTORMAP3K14FLT3PIK3CB | |
| SCHEMBL3848399 | 0.78 | MAP3K14 (0.43) | PIK3CAMTORMAP3K14EIF2AK4FLT3 | |
| SCHEMBL3849684 | 0.77 | RAB9A (0.48) | PIK3CAMTORMAP3K14EIF2AK4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |