Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845836 | 0.80 | S1PR1 (0.41) | MAP3K14FLT3PIK3CAMTOREIF2AK4 | |
| SCHEMBL3768686 | 0.80 | MAP3K14 (0.48) | L3MBTL1MAP3K14FLT3PIK3CAMTOR | |
| SCHEMBL3849418 | 0.78 | NR1H4 (0.52) | RAB9ANPC1L3MBTL1MAP3K14FLT3 | |
| SCHEMBL3846525 | 0.77 | MAP3K14 (0.48) | MAP3K14FLT3PIK3CAMTOREIF2AK4 | |
| SCHEMBL3851193 | 0.77 | MAP3K14 (0.48) | L3MBTL1MAP3K14FLT3PIK3CAMTOR | |
| SCHEMBL19586824 | 0.77 | MAP3K14 (0.45) | RAB9AL3MBTL1MAP3K14FLT3PIK3CA | |
| SCHEMBL3847032 | 0.77 | MAP3K14 (0.45) | MAP3K14FLT3PIK3CAMTOREIF2AK4 | |
| SCHEMBL3846180 | 0.77 | ALDH1A1 (0.44) | MAP3K14FLT3PIK3CAMTOREIF2AK4 | |
| SCHEMBL3847433 | 0.77 | PIK3CA (0.51) | RAB9AMAP3K14FLT3PIK3CAMTOR | |
| SCHEMBL3848399 | 0.75 | MAP3K14 (0.43) | RAB9ANPC1MAP3K14FLT3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |