Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | GPR6 | P46095 | 12/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847011 | 0.85 | CHRM4 (0.56) | CHRM4NCF1GPR6HCRTR1HCRTR2 | |
| SCHEMBL3857002 | 0.85 | CHRM4 (0.56) | CHRM4NCF1GPR6SCD | |
| SCHEMBL3846425 | 0.83 | CHRM4 (0.51) | CHRM4NCF1HCRTR1HCRTR2 | |
| SCHEMBL3847104 | 0.83 | NCF1 (0.39) | CHRM4NCF1GPR6FPR2PROKR1 | |
| SCHEMBL3845232 | 0.82 | NCF1 (0.50) | CHRM4NCF1SCDHCRTR1HCRTR2 | |
| SCHEMBL3855214 | 0.78 | CHRM4 (0.41) | CHRM4GPR6 | |
| SCHEMBL1544187 | 0.77 | NCF1 (0.62) | CHRM4NCF1HCRTR1HCRTR2 | |
| SCHEMBL14145427 | 0.76 | NCF1 (0.50) | CHRM4NCF1SCDHCRTR1HCRTR2 | |
| SCHEMBL3851336 | 0.76 | GPR6 (0.39) | CHRM4GPR6SCD | |
| SCHEMBL3848117 | 0.75 | NCF1 (0.49) | CHRM4NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |