Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850600 | 0.91 | NCF1 (0.41) | CYP2C19CLK4CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL3846233 | 0.91 | MAPKAPK2 (0.40) | CYP2C19CLK4CYP1A2CYP3A4TSHR | |
| SCHEMBL3848729 | 0.88 | CHRM4 (0.34) | CYP3A4PIK3CAMTORSYKMAPKAPK2 | |
| SCHEMBL3845803 | 0.86 | CTSS (0.33) | ALDH1A1PIK3CAMAPKAPK2HTR1AHTR1D | |
| SCHEMBL3850114 | 0.86 | MEN1 (0.35) | CYP3A4ALDH1A1PDGFRBMTORMEN1 | |
| SCHEMBL3847788 | 0.86 | CYP8B1 (0.32) | CYP3A4SYK | |
| SCHEMBL3846942 | 0.85 | SLC22A12 (0.34) | CYP3A4 | |
| SCHEMBL3847491 | 0.84 | CYP2C19 (0.45) | CYP2C19CLK4CYP1A2CYP3A4TSHR | |
| SCHEMBL3846434 | 0.83 | AKR1C3 (0.36) | CYP2C19CLK4TSHRALDH1A1MAPK1 | |
| SCHEMBL3848225 | 0.83 | PIK3CA (0.33) | ALDH1A1MAPK1LMNATP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |