SCHEMBL384760

SCHEMBL384760

ICCCc1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.74
HPGD P15428 1/20 0.74
ALOX15 P16050 1/20 0.74
ALOX12 P18054 1/20 0.74
CASP1 P29466 1/20 0.74
HSD17B10 Q99714 1/20 0.74
SIGMAR1 Q99720 5/20 0.54
MAOA P21397 1/20 0.54
MAOB P27338 2/20 0.52
HTR2A P28223 1/20 0.52
IDO1 P14902 1/20 0.50
HDAC3 O15379 1/20 0.50
MAPK1 P28482 1/20 0.50
ADRA1A P35348 1/20 0.50
HDAC4 P56524 1/20 0.50
SLC6A3 Q01959 1/20 0.50
HDAC1 Q13547 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC2 Q92769 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7544128 0.97 ALDH1A1 (0.70) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL445067 0.92 ALDH1A1 (0.70) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL3625544 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL6683681 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
Hydrochloric Acid SCHEMBL28408129 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL6379725 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL2112457 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8500856 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL282602 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL6680538 0.90 ALDH1A1 (0.67) ALDH1A1HPGDALOX15ALOX12CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 349 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509426-B1 Carbon-14 radioisotope-labeled flonicamid and synthesis method thereof Zhejiang Isotope Labelled Compounds Co., Ltd (CN) 2025-12-30 US claimed
CN-119285540-B Radioisotope carbon-14 labeled flonicamid and synthesis method thereof 浙江爱索拓标记医药科技有限公司 2025-04-04 CN claimed
CN-119285540-A Radioisotope carbon-14 labeled flonicamid and synthesis method thereof 浙江爱索拓标记医药科技有限公司 2025-01-10 CN claimed
CN-116406213-A Chemical method for inhibiting ion diffusion in perovskite battery 华东理工大学 2023-07-07 CN claimed
CN-1279022-C Sulfonated alkyl aromatic diamine and its hydrochloride and method for preparing same UNIV SHANGHAI JIAOTONG (CN) 2006-10-11 CN claimed
CN-1634880-A Sulfonated alkyl aromatic diamine and its hydrochloride and method for preparing same UNIV SHANGHAI JIAOTONG (CN) 2005-07-06 CN claimed
EP-4747260-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
US-20260070927-A1 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE HOFFMANN-LA ROCHE INC. (US) 2026-03-12 US disclosed
US-12509426-B1 Carbon-14 radioisotope-labeled flonicamid and synthesis method thereof Zhejiang Isotope Labelled Compounds Co., Ltd (CN) 2025-12-30 US disclosed
US-20250188078-A1 SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE CORNELL UNIVERSITY (US) 2025-06-12 US disclosed
EP-4536662-A1 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2025-04-16 EP disclosed
CN-119285540-B Radioisotope carbon-14 labeled flonicamid and synthesis method thereof 浙江爱索拓标记医药科技有限公司 2025-04-04 CN disclosed
WO-2025021666-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2025-01-30 WO disclosed
CN-1049347-A Novel 1-oxa--2-oxo-8-azaspiro [4,5] decane derivative, the method that contains the pharmaceutical composition of this analog derivative and prepare them RICHTER GEDEON VEGYESZET (HU) 1991-02-20 CN disclosed
EP-0015776-B1 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME ELI LILLY AND COMPANY (US) 1982-06-30 EP disclosed
US-4277471-A 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment ELI LILLY AND COMPANY (US) 1981-07-07 US disclosed
EP-0015776-A1 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same ELI LILLY AND COMPANY (US) 1980-09-17 EP disclosed
US-4198429-A BRONCHOSPASMOLYTIC HOECHST AKTIENGESELLSCHAFT (DE) 1980-04-15 US disclosed
US-4087426-A Oxybisberberine and a process for its production RESEARCH CORPORATION (US) 1978-05-02 US disclosed
US-3956237-A HINDERED UREA OR THIOUREA THE DOW CHEMICAL COMPANY (US) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509426-B1 Carbon-14 radioisotope-labeled flonicamid and synthesis method thereof TMEM14C, RPL14, FOS ALDH1A1 2800/4885HPGD 4520/4885ALOX15 3444/4885
US-20250188078-A1 SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE DDB1, CUL4A, CUL4B ALDH1A1 2081/4885HPGD 3160/4885ALOX15 4237/4885
US-20260070927-A1 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE MALT1, CCR1, CCR6 ALDH1A1 335/4885HPGD 4335/4885ALOX15 2178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.