Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848697 | 0.88 | ALDH1A1 (0.45) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL3847053 | 0.87 | NPC1 (0.46) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL3871634 | 0.84 | ALDH1A1 (0.42) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3853878 | 0.82 | CA1 (0.39) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL3847872 | 0.80 | MAPT (0.57) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3849378 | 0.78 | MAPT (0.50) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL3847806 | 0.76 | TMIGD3 (0.37) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3848293 | 0.76 | ALDH1A1 (0.41) | NPC1RAB9AMAPTALDH1A1SCD | |
| SCHEMBL3871629 | 0.76 | ALDH1A1 (0.44) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3847648 | 0.75 | MAPT (0.48) | NPC1RAB9AMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |