Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29771432 | 0.80 | L3MBTL1 (0.41) | AXLMEN1KMT2A | |
| SCHEMBL3847999 | 0.78 | KCNN4 (0.38) | DYRK1ACYP1A2MEN1KMT2A | |
| SCHEMBL3848404 | 0.77 | DYRK1A (0.38) | DYRK1APIK3CARETTGFBR1FAAH | |
| SCHEMBL1576521 | 0.76 | DYRK1A (0.73) | DYRK1APIK3CARETTGFBR1FAAH | |
| SCHEMBL70574 | 0.76 | L3MBTL1 (0.44) | DYRK1ARETMEN1KMT2A | |
| SCHEMBL3850087 | 0.76 | TGFBR1 (0.49) | DYRK1APIK3CARETTGFBR1FAAH | |
| SCHEMBL3852711 | 0.75 | CLK1 (0.36) | PIK3CARETTGFBR1FLT3 | |
| SCHEMBL3846145 | 0.74 | CYP1A2 (0.45) | DYRK1APIK3CARETTGFBR1FAAH | |
| SCHEMBL4713313 | 0.73 | IRAK4 (0.41) | PIK3CATGFBR1FLT3TGFBR2 | |
| SCHEMBL1832961 | 0.73 | DYRK1A (0.58) | DYRK1ATGFBR1FLT3KEAP1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |