Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519708 | 0.88 | KDM4E (0.33) | PTGS2SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3846801 | 0.85 | KMT2A (0.40) | PTGS2SMN1; SMN2MEN1THRBKMT2A | |
| SCHEMBL3846711 | 0.84 | KDM4E (0.37) | PTGS2TP53GAAMEN1KMT2A | |
| SCHEMBL3847281 | 0.84 | POLB (0.39) | PTGS2MAOBMEN1KMT2APOLB | |
| SCHEMBL3847801 | 0.83 | KIF11 (0.40) | MEN1KMT2AKIF11NPC1RAB9A | |
| SCHEMBL3848108 | 0.82 | MEN1 (0.46) | PTGS2PTGS1SMN1; SMN2TP53MEN1 | |
| SCHEMBL3854383 | 0.82 | NOX1 (0.36) | SMN1; SMN2TP53MEN1KMT2ANPC1 | |
| SCHEMBL3850096 | 0.82 | PTGS2 (0.39) | PTGS2PTGS1ALDH1A3MAOBSMN1; SMN2 | |
| SCHEMBL3845762 | 0.81 | PRKDC (0.36) | ALDH1A3MEN1KMT2AKIF11NPC1 | |
| SCHEMBL3850398 | 0.79 | CCR6 (0.39) | SMN1; SMN2TP53GAAKIF11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |