Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | S100B | P04271 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003451 | 0.87 | NOTUM (0.42) | NOTUMS1PR1S100B | |
| SCHEMBL24309870 | 0.83 | ASIC3 (0.52) | NOTUMPDE3BPDE3AHSD11B1 | |
| Hydrochloric Acid SCHEMBL29813270 | 0.79 | ALDH1A1 (0.60) | NOTUMS1PR1HSD11B1 | |
| SCHEMBL30336413 | 0.79 | ALDH1A1 (0.59) | NOTUMS100B | |
| SCHEMBL13419179 | 0.79 | NOTUM (0.50) | NOTUMS1PR1PDE3BPDE3AHSD11B1 | |
| SCHEMBL25194643 | 0.79 | ALDH1A1 (0.59) | NOTUMS100B | |
| SCHEMBL249224 | 0.79 | NOTUM (0.50) | NOTUMS1PR1PDE3BPDE3A | |
| SCHEMBL1929368 | 0.79 | ALDH1A1 (0.59) | NOTUMS100B | |
| SCHEMBL12648860 | 0.79 | NOTUM (0.47) | NOTUMS1PR1PDE3BPDE3AHSD11B1 | |
| SCHEMBL10088914 | 0.79 | NOTUM (0.47) | NOTUMS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1921863-B | Immunosuppressant compounds and compositions | IRM LLC | 2013-04-03 | — | — | CN | disclosed |
| US-7572811-B2 | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2009-08-11 | — | — | US | disclosed |
| EP-1718307-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2009-04-29 | — | — | EP | disclosed |
| US-20070203100-A1 | Immunosuppressant Compounds and Compositions | IRM LLC (BM) | 2007-08-30 | — | — | US | disclosed |
| EP-1718307-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM, LLC (BM) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082089-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203100-A1 | Immunosuppressant Compounds and Compositions | ICOS, EDNRA, NFATC1 | NOTUM 3843/4885S1PR1 133/4885S100B 2367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.