SCHEMBL3850180

SCHEMBL3850180

C=CCc1ccccc1[SiH2]Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 2/20 0.42
GABRB2 P47870 2/20 0.42
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 1/20 0.34
AKR1B1 P15121 1/20 0.33
ADRA2C P18825 3/20 0.33
ADRA2B P18089 2/20 0.33
HTR1A P08908 2/20 0.33
ADRA2A P08913 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
ADRB2 P07550 3/20 0.32
ADRB1 P08588 3/20 0.32
LMNA P02545 1/20 0.32
ADRB3 P13945 1/20 0.32
SLC6A2 P23975 1/20 0.32
BDKRB2 P30411 1/20 0.32
SLC6A4 P31645 1/20 0.32
ADRA1A P35348 1/20 0.32
HTR2B P41595 1/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5493042 0.82 GABRA1 (0.43) GABRA1GABRB2ALDH1A1AKR1B1LMNA
SCHEMBL9715859 0.80 TLR8 (0.31)
SCHEMBL15848437 0.79 GABRA1 (0.47) GABRA1GABRB2ALDH1A1KDM4EAKR1B1
SCHEMBL29763626 0.77 GABRA1 (0.56) GABRA1GABRB2ALDH1A1KDM4EAKR1B1
SCHEMBL173300 0.77 GABRA1 (0.56) GABRA1GABRB2ALDH1A1KDM4EAKR1B1
SCHEMBL906237 0.75 GABRA1 (0.39) GABRA1GABRB2ALDH1A1KDM4EADRA2C
SCHEMBL9715821 0.74 TDP1 (0.42) ALDH1A1LMNATSHR
SCHEMBL9715832 0.74 TDP1 (0.42) ALDH1A1LMNATSHR
SCHEMBL9715878 0.74 TDP1 (0.42) ALDH1A1LMNATSHR
Phosphine SCHEMBL28908229 0.74 GABRA1 (0.54) GABRA1GABRB2ALDH1A1KDM4EAKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023072128-A1 COLORANT COMPOSITION AND COATED ARTICLE GUANGDONG HUARUN PAINTS CO., LTD. (CN) 2023-05-04 WO claimed
CN-113956727-A Colorant composition and coated article 广东华润涂料有限公司 2022-01-21 CN claimed
WO-2023072128-A1 COLORANT COMPOSITION AND COATED ARTICLE GUANGDONG HUARUN PAINTS CO., LTD. (CN) 2023-05-04 WO disclosed
CN-110835354-B Process for preparing alkyl phenyl fluorosilane 张家港市国泰华荣化工新材料有限公司 2022-10-04 CN disclosed
EP-3039080-B1 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DUPONT TORAY SPECIALTY MATERIALS KK (JP) 2022-05-11 EP disclosed
CN-113956727-A Colorant composition and coated article 广东华润涂料有限公司 2022-01-21 CN disclosed
CN-113214651-A Curable silicone composition, cured product thereof, and optical semiconductor device 杜邦东丽特殊材料株式会社 2021-08-06 CN disclosed
EP-3133105-B1 HYDROSILYL-CONTAINING ORGANOPOLYSILOXANE, MAKING METHOD, ADDITION CURABLE SILICONE COMPOSITION, AND SEMICONDUCTOR PACKAGE SHINETSU CHEMICAL CO (JP) 2020-12-09 EP disclosed
CN-105988337-B Developing roller, toner, and image forming apparatus 株式会社理光 2020-03-10 CN disclosed
CN-110835354-A Process for preparing alkyl phenyl fluorosilane 张家港市国泰华荣化工新材料有限公司 2020-02-25 CN disclosed
US-10336913-B2 Curable silicone composition, cured product thereof, and optical semiconductor device DOW CORNING TORAY CO., LTD. (JP) 2019-07-02 US disclosed
US-5098981-A POLYORGANOSILOXANE CHISSO CORPORATION (JP) 1992-03-24 US disclosed
EP-0349920-A2 Polyorganosiloxane Chisso Corporation (JP) 1990-01-10 EP disclosed
US-4505542-A Thermostatic fiber optic waveguides RAYCHEM CORPORATION (US) 1985-03-19 US disclosed
US-4417782-A Fiber optic temperature sensing RAYCHEM CORPORATION (US) 1983-11-29 US disclosed
US-4373768-A Thermostatic fiber optic waveguides RAYCHEM CORPORATION (US) 1983-02-15 US disclosed
EP-0037266-A2 Method and apparatus for controlling the temperature of or indicating the presence of a material by means of a waveguide, heat activatable articles incorporating waveguides; and novel waveguides and a method of making such waveguides RAYCHEM CORPORATION (a California corporation) (US) 1981-10-07 EP disclosed
EP-0008997-B1 THERMOPLASTIC POLYSTYRENE-DIORGANOPOLYSILOXANE ELASTOMERS AND PROCESS FOR THE MANUFACTURE THEREOF RHONE-POULENC INDUSTRIES (FR) 1981-06-17 EP disclosed
US-4263401-A Thermoplastic, elastomeric polystyrene/diorganopolysiloxane block copolymers RHONE-POULENC INDUSTRIES (FR) 1981-04-21 US disclosed
EP-0008997-A2 Thermoplastic polystyrene-diorganopolysiloxane elastomers and process for the manufacture thereof RHONE-POULENC INDUSTRIES (FR) 1980-03-19 EP disclosed