Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | MET | P08581 | 14/20 | 0.52 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | TIE1 | P35590 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327746 | 0.91 | AXL (0.61) | AXLMETFLT3KDRSTK10 | |
| SCHEMBL5570609 | 0.89 | MET (0.55) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL3857019 | 0.88 | MET (0.53) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL372109 | 0.87 | MET (0.53) | METFLT3KDRFLT1FLT4 | |
| SCHEMBL3829238 | 0.87 | MET (0.52) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL3976731 | 0.86 | MET (0.56) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL19347622 | 0.86 | MET (0.51) | AXLMETFLT3KDRRET | |
| SCHEMBL3831025 | 0.86 | MET (0.51) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL4473446 | 0.86 | MET (0.51) | AXLMETFLT3KDRFLT1 | |
| SCHEMBL3832755 | 0.85 | MET (0.54) | METFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |