Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.61 |
| ▸ | MET | P08581 | 14/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | STK25 | O00506 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PAK3 | O75914 | 1/20 | 0.55 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850192 | 0.91 | AXL (0.53) | AXLMETFLT3PLK4STK25 | |
| SCHEMBL15519371 | 0.83 | MET (0.50) | AXLMET | |
| SCHEMBL5825612 | 0.81 | AXL (0.55) | AXLMETFLT3PLK4STK25 | |
| SCHEMBL2200943 | 0.81 | MET (0.53) | METSRCKDRMST1R | |
| SCHEMBL5826200 | 0.80 | FGFR2 (0.57) | AXLMETEGFRERBB2PDGFRA | |
| SCHEMBL1591146 | 0.80 | AXL (0.71) | AXLMETFLT3PLK4STK25 | |
| SCHEMBL3855044 | 0.80 | MET (0.55) | METKDRMST1R | |
| SCHEMBL1555923 | 0.79 | AXL (0.78) | AXLMETFLT3PLK4STK25 | |
| SCHEMBL1876630 | 0.79 | MET (0.61) | AXLMETFLT3PLK4STK25 | |
| SCHEMBL2328218 | 0.79 | MET (0.54) | METFLT3EGFRPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392564-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2013-10-23 | — | — | EP | disclosed |