Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | VDR | P11473 | 8/20 | 0.53 |
| ▸ | AR | P10275 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850807 | 0.93 | HDAC6 (0.54) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL3857821 | 0.91 | HDAC6 (0.55) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL3852904 | 0.90 | HDAC6 (0.52) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL13713954 | 0.89 | VDR (0.60) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL3856395 | 0.89 | VDR (0.52) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL3851531 | 0.89 | VDR (0.60) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL13714033 | 0.89 | VDR (0.52) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL3851250 | 0.89 | VDR (0.60) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL13714132 | 0.86 | VDR (0.55) | HDAC6HDAC3HDAC1VDRAR | |
| SCHEMBL1778198 | 0.85 | HDAC6 (0.64) | HDAC6HDAC3HDAC1VDRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579488-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579488-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579488-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070106095-A1 | Vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070106095-A1 | Vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070106095-A1 | Vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1687289-A1 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005051938-A1 | VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070106095-A1 | Vitamin d receptor modulators | VDR, CYP2R1, CYP24A1 | HDAC6 4352/4885HDAC3 1488/4885HDAC1 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.