Sugi Predict

Sugi Predict / Targets / CYP2R1

CYP2R1

Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cyt · Q6VVX0 · CYP2R1 on Sugi Atlas →

6,581 patent compounds predicted against CYP2R1, 4,204 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2753072 SCHEMBL2753072 0.56 3/20
SCHEMBL2752346 SCHEMBL2752346 0.52 3/20
SCHEMBL2752131 SCHEMBL2752131 0.52 3/20
SCHEMBL1165314 SCHEMBL1165314 0.47 3/20
SCHEMBL971260 SCHEMBL971260 0.42 3/20
SCHEMBL2749440 SCHEMBL2749440 0.42 3/20
SCHEMBL2752725 SCHEMBL2752725 0.41 3/20
SCHEMBL2091704 SCHEMBL2091704 0.41 3/20
SCHEMBL971261 SCHEMBL971261 0.40 3/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL2566375) 0.90 2/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL2592428) 0.90 2/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL2570005) 0.89 2/20
SCHEMBL2584612 SCHEMBL2584612 0.79 2/20
SCHEMBL2407878 SCHEMBL2407878 0.74 2/20
SCHEMBL196765 SCHEMBL196765 0.73 2/20
SCHEMBL2580241 SCHEMBL2580241 0.72 2/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL2592437) 0.70 2/20
SCHEMBL2582318 SCHEMBL2582318 0.68 2/20
SCHEMBL1180429 SCHEMBL1180429 0.67 2/20
SCHEMBL1181635 SCHEMBL1181635 0.67 2/20

Clinical trials — most relevant to CYP2R1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D PHASE4COMPLETED
Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression PHASE4UNKNOWN
The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff PHASE4COMPLETED
Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism PHASE4COMPLETED
Investigating the Effects of Hydroxyvitamin D3 on Multiple Sclerosis PHASE4UNKNOWN
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea PHASE3COMPLETED
Vitamin D and Type 2 Diabetes - Treat-To-Target PHASE3NOT_YET_RECRUITING
Vitamin D Supplementation in Cirrhotic Patients PHASE2COMPLETED
Cholecalciferol on Depressive Symptoms in Type 2 Diabetes Mellitus Patients PHASE2UNKNOWN
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction PHASE2UNKNOWN
The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients PHASE2UNKNOWN
Vitamin D Supplementation in HIV-infected Youth PHASE2COMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Vitamin D and the Free Hormone Hypothesis nanCOMPLETED
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism nanCOMPLETED
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease nanCOMPLETED
Vitamin D Analog in Vitamin D 24-hydroxylase Deficiency nanRECRUITING
Hypercalcemia After Paraffin Oil Injection nanRECRUITING
Serum and Semen Vitamin D Level With Semen Parameters nanUNKNOWN
The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients nanNOT_YET_RECRUITING
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer nanCOMPLETED
Non-inferiority RCT on Fish Waste-Derived vs. Synthetic Vitamin D Supplementation in Healthy Adults With Suboptimal Vitamin D Levels nanNOT_YET_RECRUITING
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome? nanUNKNOWN
The Efficacy of Nigella Sativa Versus VitaminD3 as Supplement Therapy in Coronavirus Disease 2019 (COVID-19) nanUNKNOWN
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies nanENROLLING_BY_INVITATION
Ultraviolet Light And Vitamin D In Subjects With Fat Malabsorption Or After Gastric Bypass Surgery nanCOMPLETED
DNA Changes That Affect Vitamin D Metabolism in Patients With Colorectal Cancer Receiving Vitamin D Supplements nanCOMPLETED
Prevalence of Serum-Vitamin D Abnormalities, Periodontitis and Anaemia in Patients With Melasma nanCOMPLETED
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CYP2R1 binder may also engage these)

ProteinNameSimilarity
Q6VVW9 — 1.000 Q6VVW9 →
P24456 — 0.995 P24456 →
P10633 — 0.995 P10633 →
Q9QUJ1 — 0.994 Q9QUJ1 →
Q9QYG5 — 0.994 Q9QYG5 →
Q64680 — 0.992 Q64680 →
P11714 — 0.991 P11714 →
P12938 — 0.990 P12938 →
P10634 — 0.989 P10634 →
Q64403 — 0.988 Q64403 →
O54749 — 0.988 O54749 →
O18963 — 0.987 O18963 →
CYP4Z1 Cytochrome P450 4Z1 0.986 landscape →
P12939 — 0.986 P12939 →
Q9QYG6 — 0.985 Q9QYG6 →
Q6GUQ4 — 0.985 Q6GUQ4 →
P56657 — 0.985 P56657 →
P24457 — 0.985 P24457 →
CYP4F3 Cytochrome P450 4F3 0.985 landscape →
Q8CIM7 — 0.985 Q8CIM7 →
P51590 — 0.985 P51590 →
P52786 — 0.985 P52786 →
Q9CX98 — 0.985 Q9CX98 →
P30437 — 0.984 P30437 →
Q6ZWL3 — 0.984 Q6ZWL3 →
Q6A152 — 0.984 Q6A152 →
CYP2J2 Cytochrome P450 2J2 0.983 landscape →
P08682 — 0.983 P08682 →
Q29488 — 0.982 Q29488 →
P24455 — 0.982 P24455 →