SCHEMBL3850877

SCHEMBL3850877

Fc1ccc(-n2ncc3cc([C](c4ccc5[nH]ccc5c4)C(F)(F)F)ccc32)cc1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.50
PGR P06401 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3847220 0.93 NR3C1 (0.49) NR3C1PGR
SCHEMBL3855185 0.84 NR3C1 (0.46) NR3C1PGR
SCHEMBL3856628 0.83 NR3C1 (0.60) NR3C1PGR
SCHEMBL3847216 0.83 NR3C1 (0.47) NR3C1PGR
SCHEMBL3850880 0.80 NR3C1 (0.56) NR3C1PGR
SCHEMBL1664492 0.79 NPC1 (0.66) NR3C1
SCHEMBL1664491 0.78 NPC1 (0.58) NR3C1
SCHEMBL3009584 0.77 NR3C1 (0.58) NR3C1PGR
SCHEMBL3006025 0.75 NR3C1 (0.49) NR3C1PGR
SCHEMBL3847224 0.73 NR3C1 (0.55) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102170-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Boehringer Ingelheim International GmbH (DE) 2009-09-23 EP claimed
WO-2008070507-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-06-12 WO claimed
EP-2102170-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Boehringer Ingelheim International GmbH (DE) 2009-09-23 EP disclosed
WO-2008070507-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-06-12 WO disclosed