Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326929 | 1.00 | SCN9A (0.58) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL2304747 | 1.00 | SCN9A (0.58) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL3335162 | 0.95 | SCN9A (0.56) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL280646 | 0.92 | SCN9A (0.58) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL17169499 | 0.92 | SCN9A (0.58) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL15312950 | 0.92 | SCN9A (0.58) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL2305169 | 0.88 | SCN9A (0.57) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL3330042 | 0.87 | SCN9A (0.54) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL280778 | 0.87 | SCN9A (0.54) | SCN9APOLBALDH1A1GAAMAPK1 | |
| SCHEMBL3330046 | 0.87 | SCN9A (0.54) | SCN9APOLBALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350090-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2015-06-03 | — | — | EP | claimed |
| US-8263606-B2 | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2012-09-11 | — | — | US | claimed |
| US-20100137299-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-06-03 | — | — | US | claimed |
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-04-27 | — | — | US | disclosed |
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-04-27 | — | — | US | disclosed |
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-04-27 | — | — | US | disclosed |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-11-10 | — | — | US | disclosed |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-11-10 | — | — | US | disclosed |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-14 | — | — | US | disclosed |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-14 | — | — | US | disclosed |
| WO-2010132352-A2 | SPIRO COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-11-18 | — | — | WO | disclosed |
| US-20100137299-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-06-03 | — | — | US | disclosed |
| US-20100137299-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-06-03 | — | — | US | disclosed |
| US-20100137299-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-06-03 | — | — | US | disclosed |
| US-20100099728-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2010-04-22 | — | — | US | disclosed |
| WO-2010045251-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS, INC. (CA) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010045251-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS, INC. (CA) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114075-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | TRPV3, TRPV1, TRPC3 | SCN9A 61/4885POLB 4607/4885ALDH1A1 1020/4885 |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | SCN9A 47/4885POLB 4753/4885ALDH1A1 953/4885 |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | SCN9A 47/4885POLB 4753/4885ALDH1A1 953/4885 |
| US-20100099728-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | TRPV3, TRPV1, TRPC3 | SCN9A 61/4885POLB 4607/4885ALDH1A1 1020/4885 |
| US-20100137299-A1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | TRPV3, TRPV1, TRPC3 | SCN9A 61/4885POLB 4607/4885ALDH1A1 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.