SCHEMBL38521

SCHEMBL38521

C=CCNc1nc(-c2ccccc2-c2ccc(OC)nc2)cs1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.53
RAB9A P51151 7/20 0.53
SMN1; SMN2 Q16637 7/20 0.53
NPC1 O15118 6/20 0.53
ALDH1A1 P00352 6/20 0.53
HPGD P15428 2/20 0.53
NFKB1 P19838 3/20 0.50
NFKB2 Q00653 3/20 0.50
RELA Q04206 3/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
LMNA P02545 3/20 0.46
KDM4E B2RXH2 2/20 0.46
TP53 P04637 2/20 0.46
ATM Q13315 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1915039 0.83 AR (0.48) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL1915546 0.79 FFAR2 (0.43) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL1915656 0.78 FFAR2 (0.48) MAPTRAB9ANPC1FFAR2CYP19A1
SCHEMBL38678 0.77 CYP19A1 (0.50) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL38611 0.75 MAPT (0.53) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL38249 0.75 CNR2 (0.48) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL1915580 0.74 CYP19A1 (0.49) MAPTRAB9ANPC1ALDH1A1MEN1
SCHEMBL1915663 0.74 AR (0.43) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL37686 0.73 NPC1 (0.63) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL37919 0.73 MAPT (0.56) MAPTRAB9ASMN1; SMN2NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011151436-A2 NOVEL COMPOUNDS, METHOD FOR USE THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM EUROSCREEN S.A. (BE) 2011-12-08 WO disclosed