SCHEMBL38611

SCHEMBL38611

C=CCNc1nc(-c2ccccc2B(O)O)cs1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.53
ALDH1A1 P00352 7/20 0.53
RAB9A P51151 6/20 0.53
SMN1; SMN2 Q16637 6/20 0.53
NPC1 O15118 5/20 0.53
KDM4E B2RXH2 3/20 0.53
NFKB1 P19838 2/20 0.53
NFKB2 Q00653 2/20 0.53
RELA Q04206 2/20 0.53
TP53 P04637 1/20 0.53
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
HPGD P15428 2/20 0.52
ATM Q13315 1/20 0.51
LMNA P02545 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL37686 0.80 NPC1 (0.63) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL37919 0.80 MAPT (0.56) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL12317543 0.79 ALDH1A1 (0.52) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL38629 0.76 MAPT (0.74) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL38521 0.75 MAPT (0.53) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL16498183 0.74 RAB9A (0.52) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL3226125 0.71 ECE1 (0.43) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL39270 0.70 NPC1 (0.67) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL12692375 0.69 NPC1 (1.00) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL38249 0.69 CNR2 (0.48) MAPTALDH1A1RAB9ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011151436-A2 NOVEL COMPOUNDS, METHOD FOR USE THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM EUROSCREEN S.A. (BE) 2011-12-08 WO disclosed